家医疗服务体系的医生表示，他借助人工智能挽救了母亲的生命，并希望自己的经验能帮助其他有帕金森病并发症的人。
An NHS doctor who says he saved his mum's life with the help of AI hopes what he learned can help others with Parkinson's Disease complications.
来自牛津郡的麻醉师埃德·帕特里克当时正守在母亲的病床前，准备与她告别，因为母亲开始出现严重且持续的癫痫发作。
Ed Patrick, an anaesthetist from Oxfordshire, was at his mother's bedside in hospital ready to say his goodbyes after she began suffering serious and continuous seizures.
他说，自己利用人工智能检索了近期的医学期刊文章，发现一种与她帕金森病药物相关的维生素缺乏可能是病因，随后医护人员给她补充了维生素，癫痫发作似乎因此停止。
Using AI to scour recent medical journal articles, he said he identified a vitamin deficiency linked to her Parkinson's medication as a possible cause, and staff then gave her a vitamin dose that appeared to stop the seizures.
医生表示，还需要进行临床试验以进一步了解情况，并警告患者不要在未经医嘱的情况下自行调整用药。
Doctors say clinical trials are needed to understand more - and warn against patients making changes to their own medication without medical advice.
慈善机构英国帕金森病协会对这一病例可能带来更多研究试验的前景表示欢迎，并称这可能“改变”部分其他帕金森病患者的护理。
Charity Parkinson's UK welcomed the prospect of more research trials in light of this case and said it could "transform care" for some others with Parkinson's.
今年5月，帕特里克说，医院工作人员打电话告诉他，他的母亲安在经历数月病情恶化后已接近死亡。
In May this year Patrick said hospital staff called to say his mother, Ann, was close to death, after she had been deteriorating over several months.
“她因持续不断的抽搐和惊厥被送往医院，”他告诉BBC广播2台杰里米·瓦因节目。
"She was taken to hospital with non-stop fits and convulsions," he told BBC Radio 2's Jeremy Vine Show.
“我接到医院医疗注册医生的电话，她告诉我，他们已经试过了所有抗癫痫药物，但都没有效果。‘抱歉，她快不行了’，那位注册医生对我说。‘我来得及赶到吗？’我问。‘可以，但你现在就得出发’，她回答说。”帕特里克说，当他赶到诺丁汉郡那家医院时，母亲“完全失去意识”，持续抽搐，并出现肾衰竭。
"I got a phone call from the hospital's medical registrar who told me they'd tried all the anti-seizure medications and they weren't working. 'Sorry, she's dying', the registrar told me. 'Do I have time to make it?', I said. 'Yes, but you've got to leave now' was her reply." When he got to the hospital in Nottinghamshire, Patrick said his mother was "totally unconscious", suffering continuous fits and going into kidney failure.
他说，自己使用谷歌的Gemini人工智能工具，汇总了与母亲病情和症状相关的近期医学期刊文章，然后把结果转告给了神经科顾问医生。
He said he used Google's Gemini AI tool to summarise recent medical journal articles relevant to his mum's condition and symptoms, and then relayed it to the neurology consultant.
“我告诉他我的发现——这些癫痫发作几乎可以肯定是维生素B6缺乏引起的罕见副作用，可能是她长期使用卡比多巴-左旋多巴多巴胺药物导致的，而这种药物是用来治疗她的帕金森病的，”他说。卡比多巴-左旋多巴是一种常用复方药物，用于提高帕金森病患者的 dopamine 水平。
"I told him what I'd discovered - that the seizures were almost certainly a rare side effect of a vitamin B6 deficiency, possibly caused by her long-term carbidopa-levodopa dopamine use, which was being used to treat her Parkinson's," he said. Carbidopa-levodopa is a combination drug commonly used to boost dopamine levels in Parkinson's patients.
医护人员同意给安静脉补充维生素B6，这似乎止住了她的癫痫发作。
Medical staff agreed to give Ann an intravenous supplement of vitamin B6, which appeared to stop her seizures.
“从那以后她再也没有发作过，”他说。“第二天，家人和医护人员都欣喜若狂。神经科医生还和我击掌庆祝。”这位会诊神经科医生是诺丁汉大学医院的布鲁诺·格兰医生，他说：“作为一名麻醉师，埃德对临床药理学有很深的理解，他的推理是合理的。
"She hasn't had a seizure since," he said. "The next day the family and medics were all ecstatic. The neurologist was high-fiving me." The consultant neurologist in question, Dr Bruno Gran from Nottingham University Hospitals, said: "As an anaesthetist, Ed has a strong understanding of clinical pharmacology and his reasoning was sound.
“我们没有预料到的是反应的速度和幅度。给予维生素B6后几分钟内，安的癫痫发作活动就停止了。
"What we did not anticipate was the speed and magnitude of the response. Within minutes of administering vitamin B6, Ann's seizure activity stopped.
“我们现在正努力提高对这一潜在问题的认识，首先从改变我们自己团队内的做法开始。尽管帕金森病影响着全球数百万人，但此前仅报告过14例类似病例。但如果从这个病例中获得的见解能够帮助临床医生在未来识别并预防类似情况，那将是一个重要而积极的成果。”此后，安的癫痫发作已完全康复，帕特里克说，她日常的帕金森病认知症状也有了显著改善。
"We are now working to raise awareness of this potential issue, beginning with changes to practice within our own team. Although Parkinson's affects millions of people worldwide, only 14 similar cases have ever been reported. But if the insights gained from this case can help clinicians identify and prevent similar situations in the future, that would be a significant and positive outcome." Ann has since made a full recovery from the seizures and Patrick said her day-to-day cognitive Parkinson's symptoms have dramatically improved.
“就像我们把妈妈找回来了，”帕特里克说。“感觉就像我们找到了一颗银弹。她思维敏捷得很。
"It's like we've got mum back", said Patrick. "It feels like we found a silver bullet. She's sharp as a tack.
“一个我们甚至不知道存在的解决办法，让她获得了非常好的生活质量。在认知方面，就像她回到了5到10年前。”帕金森病是一种影响大脑、神经系统和肌肉控制的进行性疾病。据英国帕金森病协会称，英国约有16.6万人患有这种疾病。
"She's been given a really good quality of life from a solution we never even knew was there. Cognitively, it's like she's gone back in time five to 10 years." Parkinson's is a progressive disorder that affects the brain, nervous system, and muscle control. About 166,000 people in the UK live with the condition, according to Parkinson's UK.
帕特里克认为，B6维生素可能对其他帕金森病患者有所帮助——无论是在紧急情况下，还是在某些长期认知功能下降的病例中。
Patrick believes B6 vitamins could help other Parkinson's patients, both in emergency settings, but also in some cases of long-term cognitive deterioration.
“我认为这一发现可能具有广泛的影响。我知道我母亲的医疗团队已经将她的病例分享给了其他医生，这促使该地区的医疗实践发生了改变；他们正在研究在哪些情况下补充B6维生素是合适的。”目前关于帕金森病患者体内B6维生素缺乏与疾病进展之间关系的临床证据仍然有限。专家们告诉BBC，英国大多数NHS（国家医疗服务体系）的工作人员并不了解这一关联。
"I think this has potentially wide-reaching ramifications for others. I know that mum's medical team has presented her case to colleagues and that's led to changes in practice in the region. They're looking at where B6 supplementation might be appropriate." Existing clinical evidence on the link between B6 deficiency in Parkinson's patients and any potential impact it can have is still limited. Experts told the BBC that the link is not known about by the majority of NHS staff in the UK.
不过，今年早些时候，美国食品药品监督管理局（FDA）发布了一份备忘录，指出用于治疗帕金森病的某些药物应附带关于B6维生素缺乏可能带来的健康风险的警告。
But earlier this year, the US Food and Drug Administration put out a memo saying that particular drugs used to treat Parkinson's should carry a warning about potential links to B6 deficiency.
格雷厄姆·约翰逊博士是德比市急诊医学领域的专家，他参与了相关研究的领导工作，并与帕特里克进行了讨论。他说：“有时候，最好的研究灵感来自患者的故事；现在帕金森病领域的专家可以利用这个病例，通过进一步的研究和临床试验来建立更坚实的证据基础。”帕金森病英国分会（Parkinson's UK）的首席执行官卡罗琳·拉塞尔表示：“我们支持开展更多关于B6维生素缺乏与帕金森病关系的研究试验。”
Dr Graham Johnson, a consultant in emergency medicine who co-leads the Research in Emergency Medicine in Derby group and has been discussing the case with Patrick, said: "Sometimes the best research ideas come from patients' stories, and experts in Parkinson's may now be able to use this case to build a wider evidence base through studies and clinical trials." The chief executive of Parkinson's UK, Caroline Rassell, said they "support the move towards more research trials into vitamin B6 deficiency and Parkinson's".
“我们需要更多研究来弄清这两者之间的联系；这些研究结果和建议可能会显著改善帕金森病患者的治疗效果。”拉塞尔和其他医疗专家提醒BBC，帕金森病患者在接受这些信息时应保持谨慎。
"It's needed to help us understand the connections. The findings and recommendations could transform care for people with Parkinson's." Rassell and other medics told the BBC that patients living with Parkinson's should treat this information with caution.
“这个家庭的经历肯定能提高人们对B6维生素与帕金森病药物之间关联的认识，”拉塞尔说，“不过，在做出任何药物或补充剂调整之前，务必先咨询医生的意见。”她同时鼓励有疑虑的患者与自己的医疗团队联系或拨打帕金森病英国分会的热线电话寻求帮助。
"This family's experience will definitely raise awareness of the link between vitamin B6 and Parkinson's medications," said Rassell.
伦敦大学学院医院NHS信托基金会帕金森病专家、咨询神经学家汤姆·福尔蒂尼（Tom Foltynie）教授表示：“患者应当记住，过高剂量的维生素B6同样会引发问题，因此任何对自身B6水平感到担忧的人，在寻求B6补充剂之前，都应该要求进行血液检测以检查其水平。”
"However, never make changes to medications or supplements before taking medical advice," she said, and encouraged anyone concerned to speak with their medical team or call the Parkinson's UK helpline.
“尽管人们对B6水平低下与潜在不良后果之间的这种关联有了初步的认识，但这种认识还不够深入，以至于B6仅被处方给极少数的帕金森病患者。”
Consultant neurologist Prof Tom Foltynie, who specialises in Parkinson's at University College London Hospitals NHS Trust, said: "Patients should bear in mind that excessively high doses of vitamin B6 can also cause problems, so anyone who is concerned about their B6 levels should request a blood test to check their levels before seeking B6 supplements.
“维生素水平出现适度的下降，对绝大多数人来说可能不会产生什么后果。但听到这个故事后，人们会意识到这可能非常重要，这会给许多从事帕金森病护理工作的人敲响警钟，提醒他们更定期地检查B族维生素的水平，并在必要时进行补充。”
"While there's fledgling awareness of this link between low B6 and potential risks of negative outcomes, is hasn't penetrated enough so that B6 is prescribed for more than a trivial amount of Parkinson's patients.
在癫痫发作康复后不久，安就已经恢复得足够健康，能够抱起帕金森的小孙女——她最小的孙女——并在病床上给她读故事。
"Having a modest lowering of these vitamin levels probably doesn't have consequences for the vast majority of people. But hearing this story emphasises that this is potentially very important, and it will ring bells for a great number of people who work with Parkinson's patients, to more regularly check levels of B vitamins, and supplement if needed." Not long after recovering from the seizures, Ann was fit enough to hold Patrick's baby - her youngest granddaughter - and read her a story from the hospital bed.
安说：“她简直太棒了，非常漂亮。而且我们能经常见到她。我非常非常感谢爱德华和家里的其他人。这似乎是一件小事——‘一点点维生素’就能带来生死之别。”
"She's absolutely glorious," said Ann. "Beautiful. And we get to see her quite a lot. I'm very very grateful to Edward and the rest of the family. It seems such a small thing - that a 'bit of a vitamin' could make a difference between life and death."