
阿斯利康公司首席执行官帕斯卡·索里奥(Pascal Soriot)表示,阿斯利康公司(AstraZeneca Plc)在无需重大收购的情况下拥有在2030年之后保持增长所需的条件。几周前,有人猜测与百时美施贵宝公司(Bristol Myers Squibb Co.)可能合作。
Plc has what it needs to keep growing beyond 2030 without a major acquisition, Chief Executive Officer Pascal Soriot said, weeks after speculation about a potential tie-up with Bristol Myers Squibb Co.
“我们绝对拥有我们需要的东西,”索里奥在阿斯特拉位于马萨诸塞州剑桥的新研究中心开业前接受采访时说道。
“We absolutely have what we need,” Soriot said in an interview ahead of the opening of Astra’s new research hub in Cambridge, Massachusetts.
索里奥发表上述言论之前,有报道称阿斯特拉探索与百时美施宝可能合并,引发股价下滑。这笔交易将创建世界上最大的制药公司之一。索里奥表示,虽然他不排除交易的可能性,但阿斯特拉现有的管道足够广泛,可以推动未来十年的增长。
Soriot’s comments come after reports that Astra explored a potential combination with Bristol-Myers triggered a share slide. The transaction would have created one of the world’s largest pharmaceutical companies. While he didn’t rule out dealmaking, Soriot said Astra’s existing pipeline is broad enough to propel growth well into the next decade.
“我们不是一家对自己拥有的东西感到满意的公司,”他说。“我们总是想做得更好。”但他认为,投资者可能会过度关注一两种实验药物,而忽视阿斯特拉投资组合的广度。
“We are not a company that is satisfied with what we have,” he said. “We always want to do better.”But investors, he argued, can become overly focused on one or two experimental drugs while overlooking the breadth of Astra’s portfolio.
这家英国制药商正在开发涵盖肿瘤学、代谢和罕见疾病的药物。Soriot表示,Astra认为其整个管道成功的可能性约为60%,而近年来,后期临床试验的成功率通常较高,这一比例约为75%。
The UK drugmaker has medicines in development across oncology, metabolic and rare diseases. Astra assumes roughly a 60% probability of success across its entire pipeline, Soriot said, compared with about 75% in recent years with late-stage clinical trials that typically have a higher success rate.
“如果一切顺利,我们的营业额将在2030年后彻底爆炸,”他说。
“If everything was to work, we would completely explode our turnover post 2030,” he said.
他承认,并不是每个实验产品都会成功。最近,在一项后期研究中,乳腺癌药物未能比标准治疗更能延缓疾病进展。但“我们相信我们将在2030年之后增长,并且肯定会打破共识。”部分赌注正在波士顿成型,阿斯特拉正在波士顿开设马萨诸塞州约10亿美元投资的最新部分。新的肯德尔广场研究中心将容纳2,000多名科学家,员工遍布波士顿地区,从事细胞治疗、心血管和代谢疾病以及罕见疾病等领域的工作。
Not every experimental product will succeed, he acknowledged. Recently, a breast-cancer pill failed to delay disease progression more than the standard treatment in a late-stage study. But “we believe we will grow past 2030, and definitely beat the consensus.”Part of that bet is taking shape in Boston, where Astra is opening the latest piece of a roughly $1 billion investment in Massachusetts. The new Kendall Square research center will house more than 2,000 scientists, with employees across the Boston area working in areas such as cell therapy, cardiovascular and metabolic diseases, and rare diseases.
波士顿也正在成为阿斯特拉推动肥胖问题的中心,该市场目前由礼来公司和诺和诺德公司主导。该公司花了大约两年的时间在那里组建了一个团队,领导其减肥产品组合的开发,包括口服药物和下一代方法,这些方法可能包括每月注射而不是每周注射。
Boston is also becoming the center of Astra’s push into obesity, a market currently dominated by Eli Lilly & Co. and Novo Nordisk A/S. The company has spent roughly two years assembling a team there to lead development of its weight-loss portfolio, including oral medicines and next-generation approaches that could include monthly rather than weekly injections.
索里奥说,阿斯特拉计划在竞争激烈的肥胖市场中脱颖而出,不仅治疗超重,还治疗经常伴随的更广泛的代谢问题,包括改善解决高胆固醇、高血压和糖尿病的问题。该公司正在开发药物,最终可以将减肥与治疗这些疾病的方法结合在一起。
Astra plans to differentiate in the competitive obesity market by treating not just excess weight but the broader metabolic problems that often accompany it, Soriot said, including improvements in addressing high cholesterol, hypertension and diabetes. The company is developing drugs that could eventually combine weight loss with treatments for those conditions in a single pill.
索里奥说:“我们拥有无人拥有的能力,能够联合治疗有风险因素的患者。”
“What we have that nobody has is this ability to combine and treat patients who have risk factors,” Soriot said.
波士顿开业也反映了阿斯特拉日益向美国倾斜,索里奥表示,美国的创新继续领先于欧洲。他说,阿斯特拉花了数年时间将资金引导到研发上,而对制造业的投资相对较少。现在该公司需要新的设施来支持该研究中出现的药物。
The Boston opening also reflects Astra’s growing tilt toward the US, where Soriot said innovation has continued to pull ahead of Europe. Astra spent years directing capital toward research and development, while investing relatively little in manufacturing, he said. Now the company needs new facilities to support the medicines emerging from that research.
索里奥表示,唐纳德·特朗普总统的政策加速了该行业向美国制造业的推动,尽管阿斯特拉无论如何都需要额外的产能。
President Donald Trump’s policies have accelerated the industry’s push toward US manufacturing, according to Soriot, though Astra would have needed the additional capacity regardless.
索里奥将这一转变视为全球制药领导地位更广泛竞争的一部分,这场竞争越来越多地在美国和中国之间展开,而不是与欧洲或日本之间展开。
Soriot sees the shift as part of a broader race for global pharmaceutical leadership, a contest increasingly playing out between the US and China, rather than with Europe or Japan.
竞争在波士顿是显而易见的,那里的制药商--尤其是那些致力于肥胖的制药商--的集中使得招募科学家变得更加激烈,同时也扩大了人才库。丹麦制药商Zealand Pharma A/S上周在剑桥开设了一家新工厂。索里奥说,阿斯特拉的新实验室部分目的是帮助其竞争这些工人。
The competition is visible in Boston, where a concentration of drugmakers — especially those working on obesity — has made recruiting scientists more heated, while also expanding the talent pool. Danish drugmaker Zealand Pharma A/S opened a new site in Cambridge last week. Astra’s new laboratories are partly intended to help it compete for those workers, Soriot said.
他说:“人们还必须觉得自己在一个好地方工作,在一家他们可以产生影响的公司工作。”“这就是为什么我们相信这个网站如此重要。”
“People also have to feel they work in a good place and at a company where they can make an impact,” he said. “That’s why we believe this site is so critical.”