字号·· | 护眼
美国广播公司

一些女性发现:GLP-1药物或有助于提高渴望生育母亲的受孕几率GLP-1s may help boost fertility outcomes for hopeful mothers, some women find

点「原文对照」整页切到原文,或双击某段只看那段的原文。

库存照片/盖蒂图片社STOCK PHOTO/Getty Images

在历经多年治疗才怀上前两个孩子后,30岁的阿什莉·安博恩惊讶地发现,在第二个孩子出生仅四个月后,自己又怀上了第三个孩子。她表示,这一切的“功臣”就是GLP-1这种药物。

After years of fertility treatments to become pregnant with her first two children, 30-year-old Ashlee Amborn was shocked to learn she was pregnant with her third child just four months after her second was born. The solution, she said: a GLP-1.

在接受ABC新闻采访时,安博恩透露,多年来她一直饱受多种疾病的困扰,这些疾病都严重影响了她的受孕能力:包括多内分泌代谢性卵巢综合征(PMOS,原名多囊卵巢综合征)、仅有一条输卵管能正常工作、子宫发育不全且只有两个卵巢能发挥功能。

Amborn had struggled for years with several conditions that made it difficult to become pregnant, including polyendocrine metabolic ovarian syndrome (PMOS) (formerly known as polycystic ovarian syndrome), a single functioning fallopian tube instead of two, one half of a uterus and only two functioning ovaries, she told ABC News.

第二个孩子出生后,她的PMOS症状再度加重,出现严重的炎症反应与激素失衡现象。安博恩称,当时她觉得必须采取行动才行。

When her PMOS symptoms flared up after her second child, including severe inflammation and hormone imbalance, Amborn said she felt she needed to take action.

一位医疗专家建议她服用GLP-1来缓解PMOS症状。结果仅仅服用一个月后,她便成功怀孕。

A medical professional recommended she take a GLP-1 to help with her PMOS symptoms, and after just one month of taking the medication, she was pregnant, she said.

“当时我的心情十分复杂:‘天哪,我怀孕了!’”安博恩回忆道,“我完全没接受任何生育治疗,仅仅靠服用GLP-1就实现了怀孕……那种感觉真是不可思议:‘这是怎么回事?怎么会这样呢?’”最近,南美一家医学期刊发表的一篇综述指出,对于患有肥胖症及PMOS的女性而言,使用GLP-1可能有助于改善生育状况;尤其是那些同时服用口服降糖药二甲双胍的患者,效果更为明显。

"It was kind of these mixed emotions of, 'Holy cow, I'm pregnant,'" Amborn said. "I did this on my own without fertility treatment. All it took was a GLP-1. ... It was this kind of crazy feeling that I had had was, 'What is going on and how did this happen?'" A recent review of this topic published in a South American medical journal suggests a possible link between GLP-1 usage and improved fertility outcomes in women with obesity and PMOS, especially those who are also taking an oral diabetes medication, metformin.

该综述作者认为,其背后的机制可能是GLP-1能促使患者减轻体重,从而改善胰岛素抵抗情况,进而带来诸多生殖健康方面的益处,比如提高排卵率、降低卵巢功能障碍的发生概率等。

According to the authors, one possible explanation for this is improved insulin resistance from weight loss on GLP-1s, which is associated with potential reproductive health benefits, including improved ovulation rates and decreased likelihood of ovarian dysfunction.

专门研究中年女性肥胖与健康问题的医生贾辛塔·安亚奥库在接受ABC新闻采访时指出,虽然目前尚无研究能直接证明排卵率与GLP-1使用之间存在关联,但她在临床实践中确实观察到该药物对提升女性生育能力有一定帮助。

Dr. Jacinta Anyaoku, a physician specializing in obesity and women's health in midlife, told ABC News that while there are no studies that make a direct correlation between ovulation rates and GLP-1 use, she has observed among her patients that it can help.

“体重下降时,炎症水平也会随之下降,”阿尼亚库说。“这实际上有助于提高排卵率。如果炎症减轻,卵子质量可能会改善,因此这些都是使用 GLP-1 可能带来的潜在效果。”然而,根据健康专家的说法,GLP-1 类药物并非生育治疗的常规标准用药,也不应取代其他生育药物。

"When you lose weight, your inflammation goes down," Anyaoku said. "It actually can help with improving your rate of ovulation. Your egg quality could potentially improve if you have reduced inflammation, and so these are all potential effects that come with GLP-1 use." However, GLP-1s are not routinely prescribed as standard of care for fertility treatments, and they are not meant to replace other fertility drugs, according to health experts.

“重要的是在怀孕前停用 GLP-1,”阿尼亚库说。“目前的建议是在开始尝试受孕前约两个月停止服用 GLP-1。”

"It is important to discontinue your GLP-1 prior to pregnancy," Anyaoku said. "The current recommendation is to stop taking your GLP-1 about two months prior to starting to try to conceive."

减肥注射笔药物。迈克尔·西卢克/UCG/环球影像集团 via 盖蒂图片社Weight loss injection pen medications. Michael Siluk/UCG/Universal Images Group via Getty Images

新泽西州一家独立药房的药师凯伦·伯杰告诉美国广播公司(ABC News)新闻:“GLP-1 类药物的处方信息建议患者与医疗服务提供者讨论生育计划,如果在使用这些药物期间怀孕,应立即联系他们。”安伯恩说,她在服用 GLP-1 后如此轻松地怀孕,感到非常震惊,因为过去多位医生曾告诉她,怀孕会非常困难,甚至可能根本不可能。

Karen Berger, a pharmacist at an independent pharmacy in New Jersey, told ABC News that "the prescribing information for GLP-1s recommends that patients discuss pregnancy plans with their healthcare provider and contact them right away if they become pregnant while using one of these medications." Amborn said she was shocked when she got pregnant so easily after taking a GLP-1, as she was told by multiple doctors in the past that it would be very difficult to get pregnant at all, or maybe even impossible.

“产后四个月在服用 GLP-1 期间怀孕时,我说:‘这东西以前哪去了?’”安伯恩说。

"When I got pregnant four months postpartum on a GLP-1 I said, 'Where has this been?'" Amborn said.

美国妇产科医师学会警告不要在怀孕或哺乳期间使用 GLP-1 类药物。该学会建议,哺乳结束后,可考虑让部分女性开始使用 GLP-1 以支持整体健康。

The American College of Obstetricians and Gynecologists warns against the use of GLP1s during pregnancy or breastfeeding. It recommends that once breastfeeding has ended, starting a GLP-1 may be considered for some women to support their overall health.

总的来说,开始使用 GLP-1 的决定应作为一项个性化方案的一部分,由患者与医疗专业人员共同制定。

In general, the decision to start a GLP-1 should be part of an individualized plan that is made with a healthcare professional.