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一个行业正在给厌食症患者开减肥药,摧毁了他们的人生 | CNN商业An industry is prescribing weight-loss drugs to people with anorexia, devastating lives | CNN Business

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八月份,AJ·贾斯珀在家中的肖像照。AJ Jasper poses for a portrait at his home in August.

对于AJ·贾斯珀来说,被誉为奇迹的药物证明简直就是一种诅咒。

For AJ Jasper, drugs hailed as miracles have proven nothing short of a curse.

2024年,贾斯珀与他自童年起反复与之斗争的厌食症之间艰难获得的休战破裂,使他陷入了迄今为止最低谷的境地。他仅比目标体重轻几磅,但一段压力时期迫使贾斯珀寻求一种新的、革命性的减肥药物。

In 2024, a hard-won truce between Jasper and the anorexia he had battled, on and off, since childhood collapsed, sending him spiraling to his lowest ebb yet. He was only a few pounds below his target weight, but a stressful period compelled Jasper to seek out a new, revolutionary class of weight-loss medication.

贾斯珀说,他在远程医疗网站Hims & Hers提交了一份表格,谎报了体重并申请了GLP-1处方。他原本期待与医生交谈,并希望能有更多问题。然而,大约两天后,药物就送到了他家门口。“我以为会有障碍,”他在芝加哥的公寓里对CNN这样说。

Jasper said he submitted a form to the telehealth site Hims & Hers, lying about his weight and asking for a GLP-1 prescription. He expected to speak to a doctor. For there to be more questions. Yet in about two days, the medication was at his door. “I thought that there would be roadblocks,” he told CNN from his apartment in Chicago.

CNN采访了几位临床医生和饮食障碍专家,他们报告称,使用GLP-1的厌食症患者人数急剧上升,其中许多人通过远程医疗平台异常便利地获得了这些药物。

CNN spoke to several clinicians and eating disorder specialists reporting sharp rises in the numbers of patients with anorexia using GLP-1s, many of whom obtained them via telehealth platforms with remarkable ease.

全球有数百万人使用这些药物减肥,但它们的普遍存在使一些患有厌食症的人难以康复或保持康复状态。

Millions of people worldwide are using the drugs to lose weight, but their omnipresence has made it difficult for some people who have anorexia to recover or to remain in recovery.

AJ Jasper 于 8 月在家中拍摄肖像照。CNN 记者 Joshua Lott 摄AJ Jasper poses for a portrait at his home in August. Joshua Lott for CNN

2023年8月,AJ·贾斯珀在其住所接受肖像拍摄。约书亚·洛特/ CNN根据华盛顿大学健康指标与评估研究所2023年的最新估计,全球约有390万人患有神经性厌食症——这是一种复杂的精神健康和饮食障碍,患者会严重限制能量摄入以减轻体重。路易斯维尔大学和研究机构RTI国际发表的一项研究显示,在436名患有饮食障碍的成年人中,目前被诊断为厌食症的人中有略高于20%的人曾经使用过GLP-1——这一比例高于报告曾经为减肥而使用该药物的美国成年人的15%。

AJ Jasper poses for a portrait at his home in August. Joshua Lott for CNN Globally, about 3.9 million people have anorexia nervosa — a complex mental health and eating disorder in which people severely restrict their energy intake to lose weight — according to the latest estimates from 2023 by the University of Washington-based Institute for Health Metrics and Evaluation. A study of 436 adults with eating disorders, published in June by the University of Louisville and research institute RTI International, found that a little over 20% of those currently diagnosed with anorexia reported ever having used a GLP-1 — higher than the 15% of US adults who report using the drug at some point for weight loss.

40岁的贾斯珀在过去两年里多次寻求治疗、病情稳定后又复发。他从多家远程医疗网站购买药物,包括Ro、Good Life Meds、MEDVi和Priority Meds,有时会同时服用几种以追求最大疗效。他只用过复方制剂、仿制版的品牌药,因为这些药更便宜,且装在小瓶里而非预充式注射笔中——这意味着他可以注射推荐剂量的数倍。

Jasper, 40, has sought treatment and stabilized and relapsed several times in the past two years. He has purchased the drugs from a number of telehealth sites, including Ro, Good Life Meds, MEDVi and Priority Meds, sometimes taking several simultaneously to maximize the effect. He’s only ever used compounded, copycat versions of name-brand drugs, as they are cheaper and come in vials rather than pre-filled pens — meaning he could administer many times the recommended dose.

最低谷出现在1月,当时贾斯珀的治疗团队坚持让他住院。一位朋友送他去医院,当时他卧床不起,极度营养不良、体重严重过低,几乎抬不起头,心脏、肝脏和肾脏已开始衰竭。“我完全耗尽了,”他说。

The nadir came in January, when Jasper’s treatment team insisted that he check into a hospital. A friend took Jasper, who, bed-bound, had become so malnourished and so underweight that he could hardly lift his head and his heart, liver and kidneys had begun to fail. “I was completely depleted,” he said.

贾斯珀展示了一张他在1月住院时的照片。Joshua Lott for CNN/电话照片由AJ Jasper提供贾斯珀说,在网上被开具GLP-1类药物处方前,他从未与医生面对面或通过电话交谈过。Joshua Lott for CNN在这场噩梦中,贾斯珀清楚地知道,他可以轻易获得他所谓的“厌食症海洛因”,并以令人难以置信的幅度和速度减重。

Jasper shows a photo of himself when he was hospitalized in January. Joshua Lott for CNN/Phone photo courtesy AJ Jasper Jasper said he never spoke to a doctor face-to-face or on the phone before being prescribed GLP-1s online. Joshua Lott for CNN Throughout the nightmare, Jasper knew he could easily obtain what he describes as “anorexic heroin” and drop weight at a bewildering scale and speed.

Jasper 展示了一张自己于 1 月住院时的照片。CNN 记者 Joshua Lott 摄/照片由 AJ Jasper 提供Jasper shows a photo of himself when he was hospitalized in January. Joshua Lott for CNN/Phone photo courtesy AJ Jasper
Jasper 表示,在通过线上渠道被开具 GLP-1 药物之前,他从未与医生面对面交谈或通过电话沟通。CNN 记者 Joshua Lott 摄Jasper said he never spoke to a doctor face-to-face or on the phone before being prescribed GLP-1s online. Joshua Lott for CNN

如果某个网站通过要求与临床医生进行视频咨询让购买GLP-1类药物变得更难,他只需换另一家。如果申请表询问他是否有饮食失调病史,他可以勾选“否”,随后一封确认邮件——通常在24小时内送达——会通知他药物已发出。美国管理远程医疗网站的规则复杂,且因州而异。

If one site made buying GLP-1s harder by requiring a video consultation with a clinician, he could simply use another. If a request form asked him about a history of eating disorders, he could tick “no,” and a confirmation email — arriving often within 24 hours — would inform him that the medication was already on its way. Rules governing telehealth sites in the United States are complicated and vary state by state.

所有州都要求临床医生在开具处方前与患者建立关系,这可以通过实时视频或电话通话、之前的面诊,或通过一种不那么即时的方式(如问卷)来完成。然而,根据连接健康政策中心的说法,大多数州不允许仅以问卷作为建立这种关系的唯一依据。

All require a clinician to establish a relationship with a patient before prescribing, which can happen via a real-time video or phone call, a previous in-person meeting or through a less immediate method, like a questionnaire. Most states do not, however, allow the latter to be the sole basis of this relationship, according to the Center for Connected Health Policy.

据CCHP称,贾斯珀所在的伊利诺伊州要求验光师必须进行面对面就诊以建立与患者的联系,但对于许多其他专科和处方类型,其规定则不够明确。

Illinois, where Jasper lives, requires, for example, optometrists to conduct in-person visits to establish a patient connection, but its rules are less explicit about how to do so for a raft of other specialties and prescription types, according to the CCHP.

Hims & Hers的一名发言人表示,筛查进食障碍是其处方流程中的强制性环节,与面对面预约一样,临床医生要求患者如实告知自己的健康史。

A spokesperson for Hims & Hers said that screening for eating disorders is a mandatory part of its prescribing process and that, as with in-person appointments, clinicians require patients to be honest about their health history.

“任何表明目前或过去存在进食障碍的回答,都会引发更多的临床问题,需要医生更仔细地评估,并且在许多情况下,会将患者转介至我们平台之外的专业进食障碍治疗机构,”该发言人说。

“Any answer indicating current or past disordered eating triggers additional clinical questions, closer provider review, and in many cases a referral to specialty eating disorder care off our platform,” the spokesperson said.

Ro的一名发言人表示,该公司要求所有患者填写一份包含进食障碍相关问题的初始表格。临床医生会利用这些信息“评估患者是否符合治疗资格,并可在任何时间点要求提供病历、要求进行视频评估或安排实验室检测,以进一步了解患者的健康状况。”该发言人还补充说,有进食障碍病史的患者会被建议“寻求线下医疗护理”。

A spokesperson for Ro said that it asks all patients to complete an intake form including questions about eating disorders. Clinicians use these details “to evaluate treatment eligibility and can, at any point, request records, require a video evaluation, or order lab testing to further understand a patient’s health,” the spokesperson said, adding that patients with a history of eating disorders are directed to “seek in-person care.”

自1月份以来,贾斯珀在摆脱厌食症方面取得了巨大进展。CNN记者约书亚·洛特摄这两个平台都表示,它们会定期跟进患者,以便在治疗期间发现潜在问题。贾斯珀说,他完全忽略了所有随访邮件。

Jasper has made big steps in recovery from anorexia since January. Joshua Lott for CNN Both platforms said they regularly follow up with patients to spot problems during treatment. Jasper said he ignored any check-in emails.

自 1 月以来,Jasper 在克服厌食症方面取得了巨大进展。CNN 记者 Joshua Lott 摄Jasper has made big steps in recovery from anorexia since January. Joshua Lott for CNN

远程医疗平台RXPros今年早些时候收购了PriorityMeds。RXPros的一名发言人告诉CNN:“患者安全和适当的临床监督一直是(PriorityMeds)流程的核心。”MEDVi和Good Life Meds未回应置评请求。

Telehealth platform RXPros acquired PriorityMeds earlier this year. “Patient safety and appropriate clinical oversight were central to (PriorityMeds’) processes,” a spokesperson for RXPros told CNN. MEDVi and Good Life Meds did not respond to requests for comment.

自1月份以来,贾斯珀的康复取得了巨大进展。他不想将那些自己知道已帮助许多人恢复健康的药物妖魔化,也不希望自己的故事成为又一个警示案例。但他确实希望远程医疗平台能设立更多监管措施。

Jasper has made huge leaps in recovery since January. He doesn’t want to demonize drugs that he knows are helping scores of people become healthier, nor does he want his story to be another cautionary tale. But he does want more guardrails around telehealth platforms.

普林斯顿进食障碍中心过去只收治需要全天候护理的最严重厌食症病例。但这家位于新泽西州的治疗中心最近推出了一项新计划,允许患者晚上回家,从而给予他们更多自主权。

The Princeton Center for Eating Disorders once treated only the most severe cases of anorexia that require round-the-clock care. But the New Jersey treatment center recently introduced a program allowing patients to return home for the evening, offering more autonomy.

“该计划启动以来的三个月里,GLP-1药物的使用已经对多名患者的治疗造成了重大干扰,”中心主任丽贝卡·博斯韦尔表示。

“GLP-1 medication use has, already, in the three months this program has been open, been a major interfering factor in treatment for multiple patients,” said its director, Rebecca Boswell.

她提到了一些案例:患者在完成线下就诊且厌食症诊断明确后,由医生(这些医生独立于远程医疗平台)开具了GLP-1药物。博斯韦尔说,一些不了解该病症的医生常常认同患者的观点,即抑制“进食冲动”会有所帮助。

She spoke of instances where patients were prescribed GLP-1s by physicians — working independently of telehealth platforms — after an in-person appointment and when an anorexia diagnosis had been well-established. Physicians uninformed about the condition have often agreed with a patient’s belief that silencing their “food noise” will help, she said.

在其他案例中,博斯韦尔的患者甚至从未见过医生,就通过远程医疗网站购买了GLP-1药物。

In other cases, Boswell’s patients have bought GLP-1s via telehealth sites without ever meeting a physician.

远程医疗网站在2010年代迎来了首个爆发期,当时伟哥及其他治疗勃起功能障碍的药物专利到期,使得价格更低的仿制药得以销售。

Telehealth sites hit their first jackpot in the 2010s, when Viagra and other drugs for erectile dysfunction came off patent, allowing for the sale of cheaper generics.

到了2020年代初,它们再次迎来爆发:制药巨头礼来和诺和诺德生产的GLP-1药物需求激增,导致全球供应短缺,美国监管机构因此暂时允许远程医疗公司销售配制的GLP-1药物版本。

They hit another jackpot in the early 2020s, when staggering demand for GLP-1s made by pharmaceutical titans Eli Lilly and Novo Nordisk led to a global shortage and regulators in the United States temporarily permitted telehealth companies to sell compounded versions.

整个行业在过去十年中迅速增长,其基础是对针对常见疾病(如脱发治疗和激素替代疗法)且能够私密获取的药物的需求。在疫情期间,美国放宽了部分在线处方的规定,进一步推动了这些公司的发展。

The industry as a whole has grown rapidly over the past decade and is built on the demand for drugs targeting common conditions — and that can be accessed discreetly — such as hair loss treatments and hormone replacement therapies. During the pandemic, a relaxation of some rules governing online prescribing in the US gave companies an additional boost.

但投资公司Jefferies负责医疗保健领域的高级股票分析师Brian Tanquilut表示,GLP-1这一机遇“几乎是从无到有出现的,而且没人真正预料到它会发展得如此巨大”。他表示,一些公司的商业模式依赖于大量销售某种产品,因此需要为这种药物提供便捷的处方途径。

But the GLP-1 opportunity “kind of came out of nowhere and no one really expected it to get this big,” said Brian Tanquilut, a senior equity analyst covering the healthcare sector at investment firm Jefferies. Some company business models are based on selling high volumes of a product, he said, making a smooth pathway to prescription necessary.

“GLP-1药物的处方管理相当宽松,”他指出。美国政府并未将这些药物归类为“受管制物质”——即那些可能引发成瘾或滥用风险的物质——因此监管也相对不那么严格。“基本上,任何想要这种药的人都能拿到。”

“Prescription is lax,” he noted of GLP-1s, which aren’t classed as “controlled substances” by the US government — those carrying a risk of addiction or abuse — and thus less strictly regulated. “Anyone who wants it can get it, for the most part.”

去年,耶鲁大学的研究人员验证了这一印象,他们创建了一个虚假账户,试图通过49个不同网站获取GLP-1药物的处方。

Last year, researchers at Yale tested that impression, creating a fake profile that attempted to obtain a GLP-1 prescription through 49 different websites.

这项“秘密购物”研究发现,92%的网站最终都开具了该类药物处方,只有55%的网站询问了受试者是否有饮食障碍史,而33%的网站则要求与临床医生进行视频或电话沟通。平均而言,处方在一天内即可开出,其中两份处方甚至在五分钟或更短时间内完成。

The “secret shopper” study found that 92% of websites ultimately prescribed the drugs, only 55% asked about a history of eating disorders, and 33% mandated either a video or phone call with a clinician. On average, prescriptions were issued within a day. Two were issued in five minutes or less.

研究人员表示,这些结果表明,一些网站将“快速开处方置于全面医疗护理之上”。

Researchers said the results indicated that some websites were prioritizing “quick prescriptions over comprehensive care.”

监管机构才刚刚开始从多个角度对该行业进行整顿:在美国,针对泛滥的配药服务和误导性广告;在澳大利亚、英国和印度,则针对宽松且可能存在安全隐患的处方行为。

Regulators are just beginning to clamp down on the industry from several angles: for rampant compounding and misleading advertising in the United States, to permissive and potentially unsafe prescribing in Australia, Britain and India.

英国饮食障碍慈善组织Beat的服务开发主管Kerri Fleming表示,远程医疗提供者通常会要求患者上传照片以核实体重。她说,一些网站已经引入了“实时照片”系统以防止滥用。据Fleming称,一些患有厌食症的人会使用人工智能伪造自己的照片,或者提交朋友或家人的照片来替代。

Kerri Fleming, head of service development at Beat, a British eating disorder charity, said telehealth providers often ask patients to upload photos to help verify their weight. She said some sites have introduced a “live photo” system to prevent abuse. According to Fleming, some people with anorexia have falsified their image using artificial intelligence or by submitting one of a friend or family member instead.

“为许多远程医疗平台工作的临床医生非常清楚其中的风险,并且正努力持续改进实践,”她说。“这个领域瞬息万变,确实难以应对。”

“The clinicians that work (for many telehealth sites) are very much aware of the risks and are trying to improve practices continuously,” she said. “It’s just an ever-changing landscape that is a hard one to navigate.”

美国远程医疗协会首席执行官凯尔·泽布利(Kyle Zebley)表示,当患者被要求自行报告自身问题时,无论是线上还是线下诊疗,错误处方的风险都是一样的。

Kyle Zebley, chief executive officer of the American Telemedicine Association, said the risk of misprescribing is the same across virtual and face-to-face settings when patients are trusted to report on their own problems.

泽布利在一份声明中称:“一份可以通过虚假信息被操纵的问卷,反映的是临床管理上的失败,而非远程医疗特有的问题。”他还补充说,美国远程医疗协会支持“对任何在患者安全问题上偷工减料的公司或临床医生进行严格执法。”

“A questionnaire that can be gamed with false information is a clinical governance failure, not a telehealth-specific one,” Zebley said in a statement, adding that the ATA supports “rigorous enforcement against any company or clinician cutting corners on patient safety.”

礼来公司的一位发言人对CNN表示,为其GLP-1类药物(包括Mounjaro和Zepbound)开具处方的远程医疗提供者是独立运营的,“他们在治疗患者时会依据自身的临床判断。”该发言人还表示,礼来“不推广也不鼓励”将该公司药物用于未经批准的适应症。

A spokesperson for Eli Lilly told CNN that telehealth providers prescribing its GLP-1 medications – including Mounjaro and Zepbound – operate independently and that “they use their own clinical judgement when treating patients.”Lilly “does not promote or encourage” the use of its drugs for unapproved conditions, the spokesperson said.

诺和诺德公司(Novo Nordisk)的传播总监梅特·克鲁塞·丹尼尔森(Mette Kruse Danielsen)表示,患者安全是公司的“首要任务”,其产品“并未获批用于治疗进食障碍”。

Mette Kruse Danielsen, a communications director for Novo Nordisk, the maker of Ozempic and Wegovy, said patient safety is a “top priority” for the company and that its products are “not approved for the treatment of eating disorders.”

厌食症是所有精神疾病中死亡率最高的疾病之一。临床医生告诉CNN,患者频繁使用GLP-1类药物以及这类药物在文化中的普遍存在,正在改变治疗方法。

Anorexia has one of highest mortality rates of any psychiatric disorder, and clinicians told CNN that frequent GLP-1 use among patients as well as the drug’s cultural ubiquity are changing approaches to treatment.

在纽约市迈阿密山奈医学院伊坎医学院的诊所中,汤姆·希尔德布兰特(Tom Hildebrandt)与厌食症患者进行的所有谈话中,都会提到这一点。许多患者表示,他们被服用这些药物的家人和朋友所包围。他说,有一位患者甚至在一次聚会上被递给了GLP-1类药物。

They are “part of every conversation” Tom Hildebrandt is having with anorexia patients in his clinic at the Icahn School of Medicine at New York City’s Mount Sinai, many of whom report feeling encircled by family and friends taking the drugs. One patient, he said, was offered a GLP-1 at a party.

Tom Hildebrandt 于 2026 年 9 月出现在纽约西奈山进食与体重障碍项目办公室内。Emmalee Reed/CNN 摄Tom Hildebrandt pictured at the Mount Sinai Eating and Weight Disorders Program office in New York in September 2026. Emmalee Reed/CNN

2026年9月,汤姆·希尔德布兰特在纽约山奈进食与体重障碍项目办公室的照片。Emmalee Reed/CNN一些患者会寻求使用GLP-1类药物来平息他们内心的“食物渴望”,希尔德布兰特说道。尽管有越来越多的证据表明,这些药物可能对部分患有暴食症或贪食症的人具有有效治疗作用,但CNN采访的临床医生们一致拒绝承认任何声称的、对厌食症的治疗益处。

Tom Hildebrandt pictured at the Mount Sinai Eating and Weight Disorders Program office in New York in September 2026. Emmalee Reed/CNN Some patients seek out GLP-1s to quiet their “food noise,” Hildebrandt said. And while there is emerging evidence that the drugs could be an effective treatment for some people with binge eating disorder or bulimia, clinicians interviewed by CNN were unanimous in their rejection of any purported therapeutic benefit for anorexia.

当身体处于饥饿状态时,大脑会陷入一种持续不断且常常令人痛苦的关于食物的思维循环。这是一种适应性反应,旨在优先恢复营养,而临床医生们试图加以利用,而非将其彻底消除。

When the body is starving, the brain will return an incessant and often distressing loop of thoughts about food, an adaptive response designed to prioritize renourishment that clinicians try to harness rather than shut down.

位于芝加哥的贾斯珀深知压制这些饥饿信号所带来的风险。在服用GLP-1类药物之前,他曾形容自己在与厌食症斗争期间就像一台“行走的计算器”,不停地计算摄入和消耗的热量。但他表示,这些药物让他变成了一个“僵尸”。对食物的痴迷、恐惧甚至噩梦都消失了,但贾斯珀对自己病情严重性的认知也随之丧失。

Jasper, in Chicago, understands the risk of silencing those hunger cues. He described himself as a “walking calculator” during periods of struggle with anorexia before taking GLP-1s, incessantly tracking calories ingested and expended. But he said the drugs turned him into a “zombie.”The food obsessions, fears and even nightmares went away, but so too did Jasper’s grasp of the seriousness of his condition.

“我甚至无法完全意识到自己正在一步步走向死亡……服用药物后,我从未意识到自己有多营养不良,因为我根本不再思考食物。”他说道。

“(I wasn’t) even able to fully comprehend that I was actively dying. … With the medication, I was never able to realize how malnourished I was because I wasn’t thinking about food at all,” he said.

他发起了一项请愿,希望引起立法者的注意,呼吁对在线处方实施新的安全措施。“这简直就像狂野的西部一样混乱,”贾斯珀说。

He has created a petition he hopes will attract the attention of lawmakers, urging the introduction of new safeguards around online prescribing. “It’s the wild, wild West,” said Jasper.

如果你或你认识的人正在与饮食障碍作斗争,请寻求帮助。在美国,可拨打美国饮食障碍联盟的免费热线电话:1-866-662-1235。国际援助机构名录可在eatingdisorderhope.com网站上查阅。

If you or someone you know is struggling with an eating disorder, help is available. In the United States, call the National Alliance for Eating Disorders’ helpline for free on 1-866-662-1235. A list of international directories is provided on eatingdisorderhope.com .