
旨在更早发现难以诊断的腹部癌症,包括肝癌、卵巢癌和胰腺癌。作者:Michelle Roberts 一款旨在一次性检测多种癌症的新型血液检测,将作为一项试验的一部分,在英格兰约200家全科诊所为英国国民保健署(NHS)患者提供。
The aim is to detect hard-to-diagnose abdominal cancers, including liver, ovarian and pancreatic cancer, much sooner. By Michelle Roberts New blood tests designed to check for multiple cancers in one go will be offered to NHS patients in some 200 GP surgeries in England as part of a trial.
旨在更早发现难以诊断的腹部癌症,包括肝癌、卵巢癌和胰腺癌。这些癌症往往在扩散后才被发现。
The aim is to detect hard-to-diagnose abdominal cancers, including liver, ovarian and pancreatic cancer, much sooner. These cancers are often found only after they have spread.
这些检测旨在寻找血液中可能预示癌症的蛋白质或DNA片段。结果可能帮助医生决定哪些出现模糊症状的患者需要进一步检查。
The tests look for proteins or fragments of DNA in the blood that may signal cancer. Results could help doctors decide which patients with vague symptoms need further investigations.
超过20,000名年龄在45岁及以上、出现疼痛或持续腹胀等症状的患者将有资格参与。
More than 20,000 patients aged 45 and over with symptoms such as pain or persistent bloating will be eligible to take part.
难以检测的癌症 这项由政府资助、由伯明翰大学主导的试验将评估这些检测是否足够准确,以便在英国国民保健署更广泛使用。一种能够识别多种癌症的血液检测的想法并非新鲜事。
Hard-to-detect cancers The government-funded trial, led by the University of Birmingham, will assess whether the tests are accurate enough for wider NHS use. The idea of a blood test that can identify multiple cancers is not new.
英国国民保健署另一项名为Galleri的检测试验最近未能实现降低晚期癌症诊断率的主要目标,尽管研究人员仍在评估其潜在益处。
A separate NHS trial of a test called Galleri recently failed to meet its main goal of reducing diagnoses of late-stage cancers, although researchers are still assessing its potential benefits.
英国国民保健署英格兰癌症全国临床主任彼得·约翰逊教授表示,早期发现腹部癌症“非常困难”,因为症状很容易被误认为其他不太严重的疾病。早期诊断能让患者获得成功治疗和生存的更大机会。
Prof Peter Johnson, NHS England's national clinical director for cancer, said detecting abdomen cancer early was "notoriously difficult" because symptoms can easily be mistaken for other less serious conditions. Earlier diagnosis gives patients a much better chance of successful treatment and survival.
每年约有71,000人在英格兰被诊断出患有胰腺癌、胃癌、肝癌、卵巢癌或结肠癌,其中近35,000人死于这些疾病。
Around 71,000 people in England are diagnosed each year with pancreatic, stomach, liver, ovarian or bowel cancer, and nearly 35,000 die from these diseases.
新的STRIDE-RCT试验旨在检测结肠癌、小肠癌、胃癌、食管癌、胰腺癌、肝癌、胆管和胆囊癌、卵巢癌、子宫内膜癌、肾癌、膀胱癌和前列腺癌。患者将在全科诊所提供一到两管血液,与常规检测一起进行。
The new STRIDE-RCT trial is about detecting bowel, small bowel, stomach, oesophageal, pancreatic, liver, bile duct and gallbladder, ovarian, endometrial, kidney, bladder and prostate cancer. Patients will provide one or two tubes of blood, taken at their GP practice, alongside routine tests.
科学家随后将分析样本,寻找癌症迹象,如果发现迹象,可能能够确定肿瘤在体内的位置。
Scientists will then analyse the samples for signs of cancer and, if present, may be able to pinpoint where in the body the tumour is located.
阳性结果并不自动意味着患有癌症,阴性结果也不能保证完全健康。
A positive result does not automatically mean there is cancer, and a negative result is not a guaranteed all-clear.
卫生大臣伊薇特·库珀表示,她希望像这样的简单血液检测能帮助更早地识别出需要紧急检查的患者。
Health secretary Yvette Cooper said she hoped simple blood tests such as these would help identify patients needing urgent investigation much sooner.
英国癌症研究机构的米歇尔·米切尔表示:“全科医生长期以来一直需要更好的工具,帮助他们通过识别哪些患者需要进一步检测来应对这种不确定性,而这项在英格兰开展的试验是满足这一需求的重要一步。”
Michelle Mitchell from Cancer Research UK said: "GPs have long needed better tools to help them navigate that uncertainty by identifying which patients require further testing and this trial in England is an important step towards addressing that need."