美国卫生与公众服务部（HHS）于周五向缉毒局（DEA）将合成 kratom 提取物列入管制名单的举措提出了建议，支持对这种俗称“加油站阿片类药物”的物质进行监管。今年7月，缉毒局宣布计划将 kratom 中提取的一种具有精神活性的化合物——7-羟基密托吉宁（7-OH）及其他相关化合物临时列为第一类管制物质，这意味着这些物质被认为没有公认的医疗用途，且存在极高的滥用风险。
The Department of Health and Human Services (HHS) on Friday added its recommendations to the Drug Enforcement Agency's (DEA) move to schedule synthetic kratom extracts, putting its support behind the push to regulate the substances colloquially called "gas station opioid." In July, the DEA announced plans to temporarily schedule a psychoactive compound derived from kratom called 7-hydroxymitragynine (7-OH) and other related compounds as Schedule I, placing it in a category indicating no accepted medical use and a high potential for abuse.
HHS 卫生事务助理部长布莱恩·克里斯汀海军上将建议，缉毒局在决定如何对合成浓缩 kratom 提取物进行管制时，应采用基于浓度或比例的阈值标准。虽然 7-OH 在源自东南亚的植物性 kratom 中以微量自然存在，但通过人工合成方式将这种化合物高度浓缩的产品却大量涌现，并已在加油站或烟草店随处可见。该部门建议，如果 7-OH 或相关化合物密托吉宁伪靛氧（MGPI）的浓度在“固体粉末、胶囊制剂或其他固体形态中超过每克1毫克，或在液体制剂中超过每毫升1毫克”，则应将两者均列为第一类管制物质。
HHS Assistant Secretary for Health Admiral Brian Christine recommended the DEA use concentration or ratio-based thresholds for determining how to schedule synthetically concentrated kratom extracts. While 7-OH is naturally present in trace amounts in herbal kratom, a plant originating from Southeast Asia, products synthetically concentrating the compound in high amounts have proliferated, becoming readily available in gas stations or tobacco shops. The department recommended that 7-OH and mitragynine pseudoindoxyl (MGPI), a related compound, be classified as Schedule I if either compound or a combination of both exceeds "1 milligram per gram in solid powders, encapsulated material, or other solid forms, or exceeds 1 milligram per milliliter in liquid preparations."
HHS 还建议，如果产品中 7-OH、MGPI 或两者组合的含量超过 kratom 主要精神活性生物碱——密托吉宁的1%，也应作此类分类。密托吉宁的效力远低于缉毒局和卫生与公众服务部所担忧的化合物。司法部长托德·布朗奇在一份声明中表示：“危险且令人上瘾的阿片类药物不应出现在便利店柜台后。我们国家的儿童和社区理应免受 7-OH 及其他强效合成药物等有害物质的侵害。”
HHS also recommended this classification if the amount of 7-OH, MGPI or a combination of both in a product makes up more than 1 percent of mitragynine, the primary psychoactive alkaloid in kratom that is much milder than the compounds that the DEA and HHS are concerned about. “Dangerous and addictive opioids do not belong behind convenience store counters,” Attorney General Todd Blanche said in a statement. “Our nation’s children and communities deserve protection from harmful substances like 7-OH and other powerful synthetic drugs. The actions taken by the Department of Justice today reflect our commitment to keeping Americans safe and holding drug traffickers accountable.”
“司法部今天采取的行动体现了我们保护美国人民安全、追究毒品贩运者责任的决心。”美国卫生与公众服务部（HHS）部长小罗伯特·F·肯尼迪表示：“我们听取了公众意见，遵循科学依据，并为临时管制制定了明确的推荐阈值，该阈值针对的是高浓度的7-OH和MGPI，而不会将天然植物性 kratom 笼统地划入第一类管制药物。特朗普政府将继续对助长成瘾的危险产品采取果断行动，同时确保我们的政策以严谨的科学依据为基础。”
HHS Secretary Robert F. Kennedy Jr. said: “We listened to the public, followed the science, and developed a clear recommended threshold for temporary scheduling that targets concentrated 7-OH and MGPI without sweeping natural botanical kratom into Schedule I. The Trump Administration will continue taking decisive action against dangerous products that fuel addiction while making sure our policies are grounded in rigorous science.”