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埃博拉病毒测序将肯尼亚、尼日利亚病例与刚果传播链联系起来Ebola Sequencing Links Kenya, Nigeria Cases to Congo Chain

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6月12日,在尼日利亚内罗毕的肯雅塔国家医院,护士们在模拟演练中准备接收一名患有高传染性疾病的患者。摄影师:Simon Maina/法新社/盖蒂图片社Nurses prepare to receive a patient with a highly infectious disease during a simulation exercise at the Kenyatta National hospital in Nairobi, Nigeria on June 12. Photographer: Simon Maina/AFP/Getty Images

基因组测序已将肯尼亚和尼日利亚检测到的埃博拉病例与同一传播链以及刚果民主共和国东部流行的病毒联系起来,同时也留下了乌干达可能存在未被发现传播链的可能性。

Genomic sequencing has linked Ebola cases detected in Kenya and Nigeria to the same transmission chain and to viruses circulating in eastern Democratic Republic of Congo, while leaving open the possibility of an undetected chain in Uganda.

据资深刚果病毒学家让-雅克·穆耶姆贝介绍,在尼日利亚首都阿布贾发现病例后,四个受影响国家的科学家共同审查了1126个病毒基因组。

Scientists from the four affected countries jointly reviewed 1,126 viral genomes after the Nigerian case was detected in the capital Abuja, according to Jean-Jacques Muyembe, the veteran Congolese virologist who convened the analysis.

穆耶姆贝周三表示,来自肯尼亚、尼日利亚和刚果东部贝尼的基因组形成了一个单一的遗传群体。贝尼病毒携带与肯尼亚和尼日利亚样本中相同的遗传“条形码”,包括在刚果其他已测序病毒中未见的突变。

The genomes from Kenya, Nigeria and Beni in eastern Congo form a single genetic group, Muyembe said Wednesday. The Beni virus carries the same genetic “barcode” found in the Kenyan and Nigerian samples, including a mutation not seen in other sequenced viruses from Congo.

尼日利亚患者于9月15日至10月3日访问乌干达——这一时期完全与她可能的暴露窗口期重叠——随后返回阿布贾,三天后出现症状。肯尼亚首发患者于10月1日至10月3日经由乌干达从刚果出行,当天从恩德培飞往内罗毕,尼日利亚患者也于当天从恩德培起飞。

The Nigerian patient visited Uganda from Sept. 15 to Oct. 3 — a period that entirely overlapped with her possible exposure window — before returning to Abuja and developing symptoms three days later. The Kenyan index patient traveled from Congo through Uganda from Oct. 1 to Oct. 3 before flying from Entebbe to Nairobi, while the Nigerian patient also flew from Entebbe that day.

这两份样本均不携带与乌干达5月和6月已知埃博拉传播链相关的遗传标记,意味着这些病例并非源自那些已记录在案的疫情。

Neither carry genetic markers associated with Uganda’s known Ebola transmission chains from May and June, meaning the cases weren’t descended from those documented outbreaks.

不过,测序无法确定这两名患者是在何处、由谁感染的。穆耶姆贝在一次埃博拉部长级会议上表示,科学家目前尚无法判断尼日利亚患者是通过肯尼亚传播链感染,还是两例病例均源自另一个此前未被识别的来源。

Still, sequencing cannot establish where the two patients were infected or by whom. Scientists can’t yet determine whether the Nigerian patient was infected through the Kenyan transmission chain, or whether both cases originated from a separate, previously unidentified source, Muyembe said at an ministerial meeting on Ebola.

各国正在重建患者的行动轨迹,以确定其行程是否重叠,并在重叠时识别同行旅客。乌干达被要求加强对旅客和边境地区的监测,以寻找未被识别传播链的证据。

The countries are now reconstructing the patients’ movements to determine whether their itineraries overlapped and to identify fellow travelers if they did. Uganda was asked to intensify surveillance among travelers and in border districts for evidence of an unrecognized chain.

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